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  3. /Pantoprazole

Pantoprazole

Protonix

Proton pump inhibitor • PPI

Premium
Nephrotoxic

Half-life

1 hour

Protein Binding

Metabolized By

CYP2C19, CYP3A4

External

Drugs.com

Mechanism of Action

Irreversibly inhibits H+/K+ ATPase (proton pump) in gastric parietal cells

Indications(5)

Esophageal and Gastric VaricesLiver CirrhosisPositive Helicobacter Pylori SerologyCoronary ThrombosisSupra-aortic Artery Thrombosis

Classification

Drug Class

Proton pump inhibitor

Subclass

PPI

Brand Names

Protonix

Key Properties

Half-life

1 hour

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Pantoprazole Drug Profile | PharmaGraphX