Avoid combining with other QT-prolonging agents; check electrolytes
Mechanism of action
Irreversibly inhibits EGFR with T790M resistance mutation; spares wild-type EGFR
Interactions
No curated interaction pairs are recorded for Osimertinib. This is not a statement that none exist — check a full interaction reference before combining.
Common adverse effects
Diarrhea
Rash
Dry skin
Paronychia
Stomatitis
Food, alcohol & herbal
Alcohol · minor
No significant interaction
Pharmacokinetics
Half-life
48 hours
Protein binding
95%
Metabolised by
CYP3A4
Pregnancy & lactation
Not recorded for Osimertinib. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.
Sources
Assembled from: drug index, curated drug database.
