Ondansetron

Zofran, Zofran ODT

Antiemetic • 5-HT3 receptor antagonist

QT RiskSerotoninergic

Half-life

3-6 hours

Protein Binding

70-76%

Metabolized By

CYP3A4, CYP1A2, CYP2D6

External

Selectively blocks serotonin 5-HT3 receptors in CTZ and vagal afferents

Drug Class

Antiemetic

Subclass

5-HT3 receptor antagonist

ZofranZofran ODT

Half-life

3-6 hours

Time for plasma concentration to decrease by 50%

Protein Binding

70-76%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses