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  3. /Nortriptyline

Nortriptyline

Pamelor, Aventyl

Antidepressant • Tricyclic antidepressant (TCA)

Premium
NTIQT RiskSerotoninergicCNS Depressant

Half-life

18-44 hours

Protein Binding

Metabolized By

CYP2D6

External

Drugs.com

Mechanism of Action

Inhibits reuptake of norepinephrine and serotonin; also blocks muscarinic, histamine, and alpha-1 receptors

Indications(5)

Lumbosacral RadiculopathyVestibulodyniaTemporomandibular DisorderFibromyalgia SyndromeIrritable Bowel Syndrome

Classification

Drug Class

Antidepressant

Subclass

Tricyclic antidepressant (TCA)

Brand Names

PamelorAventyl

Key Properties

Half-life

18-44 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Narrow

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Nortriptyline Drug Profile | PharmaGraphX