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  3. /Nitrofurantoin

Nitrofurantoin

Macrobid, Macrodantin, Furadantin

Antibiotic • Nitrofuran

Premium
Hepatotoxic

Half-life

20-60 minutes

Protein Binding

Metabolized By

N/A

External

Drugs.com

Mechanism of Action

Activated by bacterial nitroreductase to form reactive intermediates that damage DNA and ribosomes

Indications(5)

Urinary Tract InfectionsStress Urinary IncontinenceUrinary IncontinenceUncomplicated Urinary Tract InfectionsChronic Urinary Tract Infection

Classification

Drug Class

Antibiotic

Subclass

Nitrofuran

Brand Names

MacrobidMacrodantinFuradantin

Key Properties

Half-life

20-60 minutes

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Nitrofurantoin Drug Profile | PharmaGraphX