Naproxen

Aleve, Naprosyn, Anaprox

NSAID • Propionic acid derivative

BleedingNephrotoxic

Half-life

12-17 hours

Protein Binding

>99%

Metabolized By

CYP2C9, CYP1A2

External

Non-selective COX-1/COX-2 inhibitor, reducing prostaglandin synthesis

Drug Class

NSAID

Subclass

Propionic acid derivative

AleveNaprosynAnaprox

Half-life

12-17 hours

Time for plasma concentration to decrease by 50%

Protein Binding

>99%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses