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Naproxen

Aleve, Naprosyn, Anaprox, Vimovo, Aleve PM, Naprelan, Wal-Proxen, Treximet

NSAID • Propionic acid derivative

Premium

BleedingNephrotoxic

Half-life

12-17 hours

Protein Binding

>99%

Metabolized By

CYP2C9, CYP1A2

External

Drugs.com

Boxed warning

Cardiovascular thrombotic events (MI, stroke)
GI bleeding, ulceration, perforation

Clinical alerts

Boxed warning

2 boxed warnings

Bleeding risk

Additive with other antithrombotics and NSAIDs

Nephrotoxic

Monitor renal function; avoid other nephrotoxins where possible

Mechanism of action

Non-selective COX-1/COX-2 inhibitor, reducing prostaglandin synthesis

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Acute Pain
·Post Operative Pain
·Frozen Shoulder
·Adhesive Capsulitis
·Shoulder Pain

Interactions

No curated interaction pairs are recorded for Naproxen. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

GI upset
Dyspepsia
Headache
Dizziness
Edema

Food, alcohol & herbal

Food

Take with food or milk to reduce GI upset

Alcohol · major

Significantly increased GI bleeding risk

Herbal

Ginkgo (moderate) — Additive bleeding risk

Pharmacokinetics

Half-life: 12-17 hours
Protein binding: >99%
Metabolised by: CYP2C9, CYP1A2

Pregnancy & lactation

Not recorded for Naproxen. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement

Naproxen

Aleve, Naprosyn, Anaprox, Vimovo, Aleve PM, Naprelan, Wal-Proxen, Treximet

NSAID • Propionic acid derivative

Premium

BleedingNephrotoxic

Half-life

12-17 hours

Protein Binding

>99%

Metabolized By

CYP2C9, CYP1A2

External

Drugs.com

Boxed warning

Cardiovascular thrombotic events (MI, stroke)
GI bleeding, ulceration, perforation

Clinical alerts

Boxed warning

2 boxed warnings

Bleeding risk

Additive with other antithrombotics and NSAIDs

Nephrotoxic

Monitor renal function; avoid other nephrotoxins where possible

Mechanism of action

Non-selective COX-1/COX-2 inhibitor, reducing prostaglandin synthesis

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Acute Pain
·Post Operative Pain
·Frozen Shoulder
·Adhesive Capsulitis
·Shoulder Pain

Interactions

No curated interaction pairs are recorded for Naproxen. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

GI upset
Dyspepsia
Headache
Dizziness
Edema

Food, alcohol & herbal

Food

Take with food or milk to reduce GI upset

Alcohol · major

Significantly increased GI bleeding risk

Herbal

Ginkgo (moderate) — Additive bleeding risk

Pharmacokinetics

Half-life: 12-17 hours
Protein binding: >99%
Metabolised by: CYP2C9, CYP1A2

Pregnancy & lactation

Not recorded for Naproxen. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement