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  3. /Modafinil

Modafinil

Provigil

Wake-promoting agent • Eugeroic

Premium

Half-life

15 hours

Protein Binding

Metabolized By

CYP3A4, CYP2C19

External

Drugs.com

Mechanism of Action

Exact mechanism unknown; may involve dopamine reuptake inhibition and orexin/hypocretin system

Indications(5)

PsychosisSchizophrenia DisorderSchizoaffective DisorderMajor Depressive Disorder With Psychotic FeaturesBipolar Disorder With Psychotic Features

Classification

Drug Class

Wake-promoting agent

Subclass

Eugeroic

Brand Names

Provigil

Key Properties

Half-life

15 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Modafinil Drug Profile | PharmaGraphX