PharmaGraphX

Log in Get Started

Memantine

Namenda, Namenda XR, Namzaric

Anti-dementia • NMDA receptor antagonist

Premium

CNS Depressant

Half-life

60-80 hours

Protein Binding

45%

Metabolized By

N/A

External

Drugs.com

Clinical alerts

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Non-competitive, low-affinity antagonist at NMDA receptors, reducing glutamate excitotoxicity

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Brain Metastases From Solid Tumors
·Peripheral Nerve Disease
·Brain Tumor
·Motor Neuron Disease, Amyotrophic Lateral Sclerosis
·Major Depressive Disorder (MDD)

Interactions

No curated interaction pairs are recorded for Memantine. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Dizziness
Headache
Confusion
Constipation
Hypertension

Food, alcohol & herbal

Alcohol · moderate

Additive CNS effects

Pharmacokinetics

Half-life: 60-80 hours
Protein binding: 45%

Pregnancy & lactation

Not recorded for Memantine. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement