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  3. /Loratadine

Loratadine

Claritin, Alavert, Wal-itin D, Loradamed, Wal-vert, Allerclear, Cleartime Indoor & Outdoor Allergies, Claritin-D, Tavist Non-Sedating, Alavert D, Wal-itin

Antihistamine • Second-generation H1 antihistamine

Premium

Half-life

8.4 hours (active metabolite 28 hours)

Protein Binding

Metabolized By

CYP3A4, CYP2D6

External

Drugs.com

Mechanism of Action

Selective peripheral H1 receptor antagonist

Classification

Drug Class

Antihistamine

Subclass

Second-generation H1 antihistamine

Brand Names

ClaritinAlavertWal-itin DLoradamedWal-vertAllerclearCleartime Indoor & Outdoor AllergiesClaritin-DTavist Non-SedatingAlavert DWal-itin

Key Properties

Half-life

8.4 hours (active metabolite 28 hours)

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Loratadine Drug Profile | PharmaGraphX