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Loperamide

Imodium Multi-Symptom Relief, Imodium, Diamode, Imodium Advanced

Uncategorized

Standard

Half-life

10-14 hours

Protein Binding

97%

Metabolized By

N/A

External

Drugs.com

Clinical alerts

QT prolongation

Avoid combining with other QT-prolonging agents; check electrolytes

Mechanism of action

Activates peripheral mu-opioid receptors in GI wall, slowing motility and enhancing water/electrolyte absorption

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Healthy
·Opioid Use Disorder
·Colitis
·Diarrhea
·Malignant Genitourinary System Neoplasm

Interactions

No curated interaction pairs are recorded for Loperamide. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Constipation
Dizziness
Nausea
Abdominal cramps

Food, alcohol & herbal

Alcohol · moderate

Additive CNS depression at high doses

Pharmacokinetics

Half-life: 10-14 hours
Protein binding: 97%
Metabolised by: CYP3A4, CYP2C8

Pregnancy & lactation

Not recorded for Loperamide. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement