Liraglutide

Victoza, Saxenda

Antidiabetic • GLP-1 receptor agonist

Half-life

13 hours

Protein Binding

>98%

Metabolized By

N/A

External

Activates GLP-1 receptors, stimulating glucose-dependent insulin secretion

Drug Class

Antidiabetic

Subclass

GLP-1 receptor agonist

VictozaSaxenda

Half-life

13 hours

Time for plasma concentration to decrease by 50%

Protein Binding

>98%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

•Thyroid C-cell tumors (rodents) — contraindicated in MEN2 or personal/family history of medullary thyroid carcinoma