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Levodopa-Carbidopa

Sinemet, Sinemet CR, Rytary, Duopa

Antiparkinson • Dopamine precursor + decarboxylase inhibitor

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Half-life

1.5 hours

Protein Binding

36%

Metabolized By

DDC, COMT, MAO

External

Drugs.com

Mechanism of action

Levodopa crosses BBB and converts to dopamine; carbidopa prevents peripheral conversion

Interactions

No curated interaction pairs are recorded for Levodopa-Carbidopa. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Nausea
Dyskinesias
Orthostatic hypotension
Hallucinations
Wearing-off

Food, alcohol & herbal

Food

High-protein meals can reduce absorption — take on empty stomach or with low-protein food

Alcohol · moderate

Additive CNS depression

Herbal

Iron supplements (moderate) — Reduce levodopa absorption

Pharmacokinetics

Half-life: 1.5 hours
Protein binding: 36%
Metabolised by: DDC, COMT, MAO

Pregnancy & lactation

Not recorded for Levodopa-Carbidopa. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement