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  3. /Levodopa-Carbidopa

Levodopa-Carbidopa

Sinemet, Sinemet CR, Rytary, Duopa

Antiparkinson • Dopamine precursor + decarboxylase inhibitor

Premium

Half-life

1.5 hours

Protein Binding

Metabolized By

DDC, COMT, MAO

External

Drugs.com

Mechanism of Action

Levodopa crosses BBB and converts to dopamine; carbidopa prevents peripheral conversion

Classification

Drug Class

Antiparkinson

Subclass

Dopamine precursor + decarboxylase inhibitor

Brand Names

SinemetSinemet CRRytaryDuopa

Key Properties

Half-life

1.5 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Levodopa-Carbidopa Drug Profile | PharmaGraphX