Leflunomide

Active metabolite teriflunomide inhibits dihydroorotate dehydrogenase, blocking pyrimidine synthesis

No curated interaction pairs are recorded for Leflunomide. This is not a statement that none exist — check a full interaction reference before combining.

• Diarrhea
• Nausea
• Alopecia
• Rash
• Elevated LFTs

Half-life

15-18 days (active metabolite)

Protein binding

>99%

Metabolised by

CYP1A2, CYP2C19

Inhibits

CYP2C9

Not recorded for Leflunomide. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.