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  3. /Lamotrigine

Lamotrigine

Lamictal, Lamictal XR, Subvenite

Antiepileptic • Sodium channel blocker

Premium
CNS Depressant

Half-life

25-33 hours

Protein Binding

Metabolized By

UGT1A4

External

Drugs.com

Mechanism of Action

Stabilizes neuronal membranes by inhibiting voltage-sensitive sodium channels

Indications(5)

ManiaBipolar DisorderBipolar II DisorderBipolar Disorder Type I With ManiaHealthy Volunteers

Classification

Drug Class

Antiepileptic

Subclass

Sodium channel blocker

Brand Names

LamictalLamictal XRSubvenite

Key Properties

Half-life

25-33 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Lamotrigine Drug Profile | PharmaGraphX