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Ketorolac

Toradol, Acular, Omidria, Acuvail, Sprix

NSAID • Pyrrolizine carboxylic acid derivative

Premium

BleedingNephrotoxic

Half-life

5-6 hours

Protein Binding

99%

Metabolized By

CYP2C9

External

Drugs.com

Boxed warning

Not for perioperative pain in CABG surgery
GI bleeding, ulceration, perforation
Renal failure
Limit duration to 5 days

Clinical alerts

Boxed warning

4 boxed warnings

Bleeding risk

Additive with other antithrombotics and NSAIDs

Nephrotoxic

Monitor renal function; avoid other nephrotoxins where possible

Mechanism of action

Potent non-selective COX inhibitor with analgesic activity comparable to opioids

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·DeQuervain Tendinopathy
·Post Cataract Surgery
·Postoperative Pain
·Acute Pain
·Opioid Use Disorder

Interactions

No curated interaction pairs are recorded for Ketorolac. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Nausea
Dyspepsia
GI pain
Headache
Drowsiness

Food, alcohol & herbal

Alcohol · major

Markedly increased GI bleeding risk

Pharmacokinetics

Half-life: 5-6 hours
Protein binding: 99%
Metabolised by: CYP2C9

Pregnancy & lactation

Not recorded for Ketorolac. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement

Ketorolac

Toradol, Acular, Omidria, Acuvail, Sprix

NSAID • Pyrrolizine carboxylic acid derivative

Premium

BleedingNephrotoxic

Half-life

5-6 hours

Protein Binding

99%

Metabolized By

CYP2C9

External

Drugs.com

Boxed warning

Not for perioperative pain in CABG surgery
GI bleeding, ulceration, perforation
Renal failure
Limit duration to 5 days

Clinical alerts

Boxed warning

4 boxed warnings

Bleeding risk

Additive with other antithrombotics and NSAIDs

Nephrotoxic

Monitor renal function; avoid other nephrotoxins where possible

Mechanism of action

Potent non-selective COX inhibitor with analgesic activity comparable to opioids

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·DeQuervain Tendinopathy
·Post Cataract Surgery
·Postoperative Pain
·Acute Pain
·Opioid Use Disorder

Interactions

No curated interaction pairs are recorded for Ketorolac. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Nausea
Dyspepsia
GI pain
Headache
Drowsiness

Food, alcohol & herbal

Alcohol · major

Markedly increased GI bleeding risk

Pharmacokinetics

Half-life: 5-6 hours
Protein binding: 99%
Metabolised by: CYP2C9

Pregnancy & lactation

Not recorded for Ketorolac. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement