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  3. /Ivermectin

Ivermectin

Stromectol, Heartgard Plus, Agrimectin, Sklice, Promectin, Privermectin, Tri-Heart Plus, DuraMectin, Soolantra, Bimectin Plus, Iverhart, Prazimectin, Iverhart Plus, Ivomec Plus, Zimecterin, Bimectin, Ivermax, Equimax, Noromectin, Noromectin Plus, Vetrimec, Ivermax Plus, Vetrimec Plus, Ivomec, Zimecterin Gold

Antiparasitic • Avermectin derivative

Premium
Hepatotoxic

Half-life

18 hours

Protein Binding

Metabolized By

CYP3A4

External

Drugs.com

Mechanism of Action

Binds to glutamate-gated chloride channels in parasites, causing paralysis and death

Indications(5)

RosaceaSolid Tumor, AdultScabies; ItchScabiesOnchocerciasis

Classification

Drug Class

Antiparasitic

Subclass

Avermectin derivative

Brand Names

StromectolHeartgard PlusAgrimectinSklicePromectinPrivermectinTri-Heart PlusDuraMectinSoolantraBimectin PlusIverhartPrazimectinIverhart PlusIvomec PlusZimecterinBimectinIvermaxEquimaxNoromectinNoromectin PlusVetrimecIvermax PlusVetrimec PlusIvomecZimecterin Gold

Key Properties

Half-life

18 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Ivermectin Drug Profile | PharmaGraphX