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  3. /Infliximab

Infliximab

Remicade, Inflectra, Renflexis, Avsola, Zymfentra

Biologic • TNF-alpha inhibitor

Premium
Hepatotoxic

Half-life

7.7-9.5 days

Protein Binding

Metabolized By

Proteolytic degradation

External

Drugs.com

Mechanism of Action

Chimeric (mouse/human) monoclonal antibody against TNF-alpha

Indications(5)

Hematopoietic and Lymphoid Cell NeoplasmMalignant Solid NeoplasmSteroid-Refractory PneumonitisMelanomaInflamatory Bowel Disease (Crohn's and Ulcerative Colitis)

Classification

Drug Class

Biologic

Subclass

TNF-alpha inhibitor

Brand Names

RemicadeInflectraRenflexisAvsolaZymfentra

Key Properties

Half-life

7.7-9.5 days

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Infliximab Drug Profile | PharmaGraphX