Monitor renal function; avoid other nephrotoxins where possible
Hepatotoxic
Monitor liver function
CNS depressant
Additive sedation with other CNS depressants and alcohol
Mechanism of action
Potent non-selective COX inhibitor
Interactions
No curated interaction pairs are recorded for Indomethacin. This is not a statement that none exist — check a full interaction reference before combining.
Common adverse effects
Headache
Dizziness
GI upset
Nausea
Drowsiness
Food, alcohol & herbal
Food
Take with food to reduce GI irritation
Alcohol · major
Increased GI bleeding and CNS effects
Pharmacokinetics
Half-life
4.5 hours
Protein binding
99%
Metabolised by
CYP2C9, CYP2C19, UGT
Pregnancy & lactation
Not recorded for Indomethacin. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.
Sources
Assembled from: drug index, curated drug database.
