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  3. /Indomethacin

Indomethacin

Indocin, Tivorbex

NSAID • Indole acetic acid derivative

Premium
BleedingCNS DepressantHepatotoxicNephrotoxic

Half-life

4.5 hours

Protein Binding

Metabolized By

CYP2C9, CYP2C19, UGT

External

Drugs.com

Mechanism of Action

Potent non-selective COX inhibitor

Classification

Drug Class

NSAID

Subclass

Indole acetic acid derivative

Brand Names

IndocinTivorbex

Key Properties

Half-life

4.5 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Indomethacin Drug Profile | PharmaGraphX