Increased mortality in elderly with dementia-related psychosis
Clinical alerts
Boxed warning
1 boxed warning
QT prolongation
Avoid combining with other QT-prolonging agents; check electrolytes
CNS depressant
Additive sedation with other CNS depressants and alcohol
Mechanism of action
Antagonist at D2 and 5-HT2A receptors
Interactions
No curated interaction pairs are recorded for Iloperidone. This is not a statement that none exist — check a full interaction reference before combining.
Common adverse effects
Dizziness
Somnolence
Tachycardia
Orthostatic hypotension
Food, alcohol & herbal
Alcohol · major
CNS depression
Pharmacokinetics
Half-life
18 hours (EM); 33 hours (PM)
Protein binding
95%
Metabolised by
CYP2D6, CYP3A4
Pregnancy & lactation
Not recorded for Iloperidone. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.
Sources
Assembled from: drug index, curated drug database.
