Hydrochlorothiazide

Microzide, HydroDIURIL, Tribenzor, Exforge HCT, Tekturna HCT, Accuretic, Aldactazide, Vaseretic, Diovan HCT, Hyzaar, Lopressor HCT, Lotensin HCT, Dyazide, Avalide, Inzirqo, Atacand HCT, Micardis-HCT, Benicar HCT, Maxzide, Ziac, Zestoretic

Diuretic • Thiazide diuretic

Premium

Half-life

6-15 hours

Protein Binding

40-68%

Metabolized By

N/A

External

Drugs.com

Mechanism of action

Inhibits sodium reabsorption in the distal convoluted tubule

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Acute Heart Failure (AHF)
·Congestive Heart Failure Acute
·Diuretic Effect
·Lung Ultrasonography Score
·Ultrasonography, Doppler

Interactions

No curated interaction pairs are recorded for Hydrochlorothiazide. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Hypokalemia
Hyperuricemia
Hyperglycemia
Hyponatremia
Dizziness

Food, alcohol & herbal

Food

May be taken with food to reduce GI upset

Alcohol · moderate

Additive hypotension and orthostatic effects

Herbal

Licorice (moderate) — May worsen hypokalemia

Pharmacokinetics

Half-life: 6-15 hours
Protein binding: 40-68%

Pregnancy & lactation

Not recorded for Hydrochlorothiazide. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement