Hydrochlorothiazide

Microzide, HydroDIURIL

Diuretic • Thiazide diuretic

Half-life

6-15 hours

Protein Binding

40-68%

Metabolized By

N/A

External

Inhibits sodium reabsorption in the distal convoluted tubule

Drug Class

Diuretic

Subclass

Thiazide diuretic

MicrozideHydroDIURIL

Half-life

6-15 hours

Time for plasma concentration to decrease by 50%

Protein Binding

40-68%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses