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  3. /Glyburide

Glyburide

DiaBeta, Glynase, Micronase

Antidiabetic • Sulfonylurea

Premium
Hepatotoxic

Half-life

4-10 hours

Protein Binding

Metabolized By

CYP2C9, CYP3A4

External

Drugs.com

Mechanism of Action

Stimulates insulin release from pancreatic beta cells

Indications(5)

Type 2 Diabetes Mellitus (T2DM)Acute Spinal Cord InjuryCardiovascular EventsType2 DiabetesRenal Disease

Classification

Drug Class

Antidiabetic

Subclass

Sulfonylurea

Brand Names

DiaBetaGlynaseMicronase

Key Properties

Half-life

4-10 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Glyburide Drug Profile | PharmaGraphX