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Ethinyl Estradiol/Levonorgestrel

Alesse, Levlen, Nordette, Trivora

Contraceptive • Combined oral contraceptive

Premium

Hepatotoxic

Half-life

EE: 12-23 hours; LNG: 24-32 hours

Protein Binding

97%

Metabolized By

CYP3A4, UGT

External

Drugs.com

Boxed warning

Cigarette smoking increases risk of serious cardiovascular events — contraindicated in smokers >35 years
VTE, stroke, MI risk

Clinical alerts

Boxed warning

2 boxed warnings

Hepatotoxic

Monitor liver function

Mechanism of action

Suppresses ovulation via negative feedback on hypothalamus; thickens cervical mucus

Interactions

No curated interaction pairs are recorded for Ethinyl Estradiol/Levonorgestrel. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Nausea
Breast tenderness
Headache
Breakthrough bleeding
Mood changes

Food, alcohol & herbal

Alcohol · minor

Alcohol may increase estrogen levels

Herbal

St. John's Wort (major) — Reduces contraceptive effectiveness — breakthrough bleeding, pregnancy risk

Pharmacokinetics

Half-life: EE: 12-23 hours; LNG: 24-32 hours
Protein binding: 97%
Metabolised by: CYP3A4, UGT

Pregnancy & lactation

Not recorded for Ethinyl Estradiol/Levonorgestrel. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement

Ethinyl Estradiol/Levonorgestrel

Alesse, Levlen, Nordette, Trivora

Contraceptive • Combined oral contraceptive

Premium

Hepatotoxic

Half-life

EE: 12-23 hours; LNG: 24-32 hours

Protein Binding

97%

Metabolized By

CYP3A4, UGT

External

Drugs.com

Boxed warning

Cigarette smoking increases risk of serious cardiovascular events — contraindicated in smokers >35 years
VTE, stroke, MI risk

Clinical alerts

Boxed warning

2 boxed warnings

Hepatotoxic

Monitor liver function

Mechanism of action

Suppresses ovulation via negative feedback on hypothalamus; thickens cervical mucus

Interactions

No curated interaction pairs are recorded for Ethinyl Estradiol/Levonorgestrel. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Nausea
Breast tenderness
Headache
Breakthrough bleeding
Mood changes

Food, alcohol & herbal

Alcohol · minor

Alcohol may increase estrogen levels

Herbal

St. John's Wort (major) — Reduces contraceptive effectiveness — breakthrough bleeding, pregnancy risk

Pharmacokinetics

Half-life: EE: 12-23 hours; LNG: 24-32 hours
Protein binding: 97%
Metabolised by: CYP3A4, UGT

Pregnancy & lactation

Not recorded for Ethinyl Estradiol/Levonorgestrel. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement