Esomeprazole

Nexium, Nexium 24HR

Proton pump inhibitor • PPI

Nephrotoxic

Half-life

1-1.5 hours

Protein Binding

97%

Metabolized By

CYP2C19, CYP3A4

External

S-isomer of omeprazole; irreversibly inhibits proton pump

Drug Class

Proton pump inhibitor

Subclass

PPI

NexiumNexium 24HR

Half-life

1-1.5 hours

Time for plasma concentration to decrease by 50%

Protein Binding

97%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses