Donepezil

Aricept, Aricept ODT

Anti-dementia • Cholinesterase inhibitor

QT Risk

Half-life

70 hours

Protein Binding

96%

Metabolized By

CYP2D6, CYP3A4

External

Reversibly inhibits acetylcholinesterase, increasing ACh in the synapse

Drug Class

Anti-dementia

Subclass

Cholinesterase inhibitor

AriceptAricept ODT

Half-life

70 hours

Time for plasma concentration to decrease by 50%

Protein Binding

96%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses