Avoid combining with other QT-prolonging agents; check electrolytes
Hepatotoxic
Monitor liver function
Mechanism of action
Inhibits ALK, ROS1, and MET tyrosine kinases
Interactions
No curated interaction pairs are recorded for Crizotinib. This is not a statement that none exist — check a full interaction reference before combining.
Common adverse effects
Visual disturbances
Nausea
Diarrhea
Edema
Elevated LFTs
Food, alcohol & herbal
Alcohol · moderate
Additive hepatotoxicity
Pharmacokinetics
Half-life
42 hours
Protein binding
91%
Metabolised by
CYP3A4
Inhibits
CYP3A4
Pregnancy & lactation
Not recorded for Crizotinib. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.
Sources
Assembled from: drug index, curated drug database.
