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Colistin

Coly-Mycin M

Antibiotic • Polymyxin

NTINephrotoxic

Half-life

5 hours

Protein Binding

50%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Nephrotoxicity and neurotoxicity — use only when no alternatives

Clinical alerts

Boxed warning

1 boxed warning

Narrow therapeutic index

Small dose changes can cause toxicity or loss of effect

Nephrotoxic

Monitor renal function; avoid other nephrotoxins where possible

Mechanism of action

Disrupts bacterial outer membrane by binding lipid A of lipopolysaccharide

Interactions

No curated interaction pairs are recorded for Colistin. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Nephrotoxicity
Neurotoxicity
Paresthesias

Food, alcohol & herbal

Alcohol · minor

No significant interaction

Pharmacokinetics

Half-life: 5 hours
Protein binding: 50%

Pregnancy & lactation

Not recorded for Colistin. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement

Colistin

Coly-Mycin M

Antibiotic • Polymyxin

NTINephrotoxic

Half-life

5 hours

Protein Binding

50%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Nephrotoxicity and neurotoxicity — use only when no alternatives

Clinical alerts

Boxed warning

1 boxed warning

Narrow therapeutic index

Small dose changes can cause toxicity or loss of effect

Nephrotoxic

Monitor renal function; avoid other nephrotoxins where possible

Mechanism of action

Disrupts bacterial outer membrane by binding lipid A of lipopolysaccharide

Interactions

No curated interaction pairs are recorded for Colistin. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Nephrotoxicity
Neurotoxicity
Paresthesias

Food, alcohol & herbal

Alcohol · minor

No significant interaction

Pharmacokinetics

Half-life: 5 hours
Protein binding: 50%

Pregnancy & lactation

Not recorded for Colistin. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement