Colchicine

Colcrys, Mitigare

Antigout • Anti-inflammatory (microtubule inhibitor)

NTI

Half-life

27-31 hours

Protein Binding

39%

Metabolized By

CYP3A4

External

Disrupts microtubule assembly, inhibiting neutrophil migration and inflammatory response

Drug Class

Antigout

Subclass

Anti-inflammatory (microtubule inhibitor)

ColcrysMitigare

Half-life

27-31 hours

Time for plasma concentration to decrease by 50%

Protein Binding

39%

Fraction bound to plasma proteins

Therapeutic Index

Narrow

Margin between therapeutic and toxic doses