Clozapine Drug Profile | PharmaGraphX

Boxed warning

Agranulocytosis — requires REMS monitoring
Seizures
Myocarditis/Cardiomyopathy
Orthostatic hypotension

Clinical alerts

Boxed warning

4 boxed warnings

Narrow therapeutic index

Small dose changes can cause toxicity or loss of effect

QT prolongation

Avoid combining with other QT-prolonging agents; check electrolytes

Anticholinergic

Adds to anticholinergic burden, particularly in older patients

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Antagonizes D4, 5-HT2A, H1, muscarinic, and alpha-1 receptors with weak D2 affinity

Interactions

No curated interaction pairs are recorded for Clozapine. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Sedation
Weight gain
Hypersalivation
Constipation
Tachycardia

Food, alcohol & herbal

Food

Smoking decreases clozapine levels; dose adjustment needed if patient quits

Alcohol · major

Severe CNS depression and orthostatic hypotension

Pharmacokinetics

Half-life: 8-12 hours
Protein binding: 97%
Metabolised by: CYP1A2, CYP3A4

Pregnancy & lactation

Not recorded for Clozapine. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.