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Cinacalcet

Sensipar

Uncategorized

Standard

Half-life

30-40 hours

Protein Binding

93-97%

Metabolized By

N/A

External

Drugs.com

Clinical alerts

QT prolongation

Avoid combining with other QT-prolonging agents; check electrolytes

Mechanism of action

Allosteric modulator of calcium-sensing receptor on parathyroid gland, reducing PTH secretion

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Secondary Hyperparathyroidism
·Secondary Hyperparathyroidism, Chronic Kidney Disease
·Male Osteoporosis
·Renal Dialysis
·Children Over 3 Undergoing Dialysis With Secondary Hyperparathyroidism

Interactions

No curated interaction pairs are recorded for Cinacalcet. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Nausea
Vomiting
Diarrhea
Hypocalcemia

Food, alcohol & herbal

Food

Take with food or shortly after a meal

Alcohol · minor

No significant interaction

Pharmacokinetics

Half-life: 30-40 hours
Protein binding: 93-97%
Metabolised by: CYP3A4, CYP2D6, CYP1A2
Inhibits: CYP2D6

Pregnancy & lactation

Not recorded for Cinacalcet. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement