PharmaGraphX

Log in Get Started

Cariprazine

Vraylar

Uncategorized

Standard

Half-life

2-4 days (active metabolites: 1-3 weeks)

Protein Binding

91-97%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Increased mortality in elderly with dementia-related psychosis

Clinical alerts

Boxed warning

1 boxed warning

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Partial agonist at D2/D3 receptors; partial agonist at 5-HT1A; antagonist at 5-HT2A

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Depression
·Bipolar I Disorder
·Schizophrenia
·Treatment-resistant Schizophrenia
·Unipolar Depression

Interactions

No curated interaction pairs are recorded for Cariprazine. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Akathisia
EPS
Insomnia
Restlessness

Food, alcohol & herbal

Alcohol · major

Additive CNS depression

Pharmacokinetics

Half-life: 2-4 days (active metabolites: 1-3 weeks)
Protein binding: 91-97%
Metabolised by: CYP3A4, CYP2D6

Pregnancy & lactation

Not recorded for Cariprazine. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement

Cariprazine

Vraylar

Uncategorized

Standard

Half-life

2-4 days (active metabolites: 1-3 weeks)

Protein Binding

91-97%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Increased mortality in elderly with dementia-related psychosis

Clinical alerts

Boxed warning

1 boxed warning

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Partial agonist at D2/D3 receptors; partial agonist at 5-HT1A; antagonist at 5-HT2A

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Depression
·Bipolar I Disorder
·Schizophrenia
·Treatment-resistant Schizophrenia
·Unipolar Depression

Interactions

No curated interaction pairs are recorded for Cariprazine. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Akathisia
EPS
Insomnia
Restlessness

Food, alcohol & herbal

Alcohol · major

Additive CNS depression

Pharmacokinetics

Half-life: 2-4 days (active metabolites: 1-3 weeks)
Protein binding: 91-97%
Metabolised by: CYP3A4, CYP2D6

Pregnancy & lactation

Not recorded for Cariprazine. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement