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Canagliflozin

Invokana, Invokamet

Uncategorized

Standard

Half-life

10.6-13.1 hours

Protein Binding

99%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Increased risk of lower limb amputations (observed in CANVAS trial)

Clinical alerts

Boxed warning

1 boxed warning

Mechanism of action

Inhibits SGLT2, reducing renal glucose reabsorption; also weak SGLT1 inhibition

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Acute Ischemic Stroke From Large Vessel Occlusion
·Peripheral Arterial Disease(PAD)
·ESRD
·CKD Stage 4
·CKD Stage 5

Interactions

No curated interaction pairs are recorded for Canagliflozin. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Genital mycotic infections
UTI
Increased urination

Food, alcohol & herbal

Food

Take before first meal of the day

Alcohol · moderate

Increased dehydration risk

Pharmacokinetics

Half-life: 10.6-13.1 hours
Protein binding: 99%

Pregnancy & lactation

Not recorded for Canagliflozin. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement

Canagliflozin

Invokana, Invokamet

Uncategorized

Standard

Half-life

10.6-13.1 hours

Protein Binding

99%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Increased risk of lower limb amputations (observed in CANVAS trial)

Clinical alerts

Boxed warning

1 boxed warning

Mechanism of action

Inhibits SGLT2, reducing renal glucose reabsorption; also weak SGLT1 inhibition

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Acute Ischemic Stroke From Large Vessel Occlusion
·Peripheral Arterial Disease(PAD)
·ESRD
·CKD Stage 4
·CKD Stage 5

Interactions

No curated interaction pairs are recorded for Canagliflozin. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Genital mycotic infections
UTI
Increased urination

Food, alcohol & herbal

Food

Take before first meal of the day

Alcohol · moderate

Increased dehydration risk

Pharmacokinetics

Half-life: 10.6-13.1 hours
Protein binding: 99%

Pregnancy & lactation

Not recorded for Canagliflozin. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement