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Bosentan

Tracleer

Uncategorized

Standard

Half-life

5 hours

Protein Binding

98%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Hepatotoxicity — monthly LFT monitoring required
Teratogenicity — pregnancy must be excluded

Clinical alerts

Boxed warning

2 boxed warnings

Hepatotoxic

Monitor liver function

Mechanism of action

Blocks endothelin ETA and ETB receptors, reducing pulmonary vascular resistance

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Healthy
·Pulmonary Arterial Hypertension
·Pediatric Pulmonary Hypertension
·Resistant Hypertension
·Large Vessel Vasculitis

Interactions

No curated interaction pairs are recorded for Bosentan. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Elevated LFTs
Headache
Edema
Anemia

Food, alcohol & herbal

Alcohol · moderate

Additive hepatotoxicity risk

Pharmacokinetics

Half-life: 5 hours
Protein binding: 98%
Metabolised by: CYP3A4, CYP2C9
Induces: CYP3A4, CYP2C9

Pregnancy & lactation

Pregnancy category: X

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement

Bosentan

Tracleer

Uncategorized

Standard

Half-life

5 hours

Protein Binding

98%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Hepatotoxicity — monthly LFT monitoring required
Teratogenicity — pregnancy must be excluded

Clinical alerts

Boxed warning

2 boxed warnings

Hepatotoxic

Monitor liver function

Mechanism of action

Blocks endothelin ETA and ETB receptors, reducing pulmonary vascular resistance

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Healthy
·Pulmonary Arterial Hypertension
·Pediatric Pulmonary Hypertension
·Resistant Hypertension
·Large Vessel Vasculitis

Interactions

No curated interaction pairs are recorded for Bosentan. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Elevated LFTs
Headache
Edema
Anemia

Food, alcohol & herbal

Alcohol · moderate

Additive hepatotoxicity risk

Pharmacokinetics

Half-life: 5 hours
Protein binding: 98%
Metabolised by: CYP3A4, CYP2C9
Induces: CYP3A4, CYP2C9

Pregnancy & lactation

Pregnancy category: X

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement