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Aprepitant

Cinvanti, Aponvie, Emend

Uncategorized

Standard

Half-life

9-13 hours

Protein Binding

95%

Metabolized By

N/A

External

Drugs.com

Mechanism of action

Blocks substance P / neurokinin 1 (NK1) receptors in CTZ and brainstem

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Breast Cancer
·Type 2 Diabetes
·Hypertension
·Heart Failure
·Nausea and Vomiting, Postoperative

Interactions

No curated interaction pairs are recorded for Aprepitant. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Fatigue
Diarrhea
Hiccups
Anorexia

Food, alcohol & herbal

Alcohol · minor

No significant interaction

Pharmacokinetics

Half-life: 9-13 hours
Protein binding: 95%
Metabolised by: CYP3A4
Inhibits: CYP3A4
Induces: CYP2C9

Pregnancy & lactation

Not recorded for Aprepitant. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement