Amlodipine

Norvasc, Tribenzor, Exforge HCT, Twynsta, Prestalia, Consensi, Lotrel, Katerzia, Norliqva, Sdamlo, Widaplik, Caduet, Exforge, Azor

Calcium channel blocker • Dihydropyridine CCB

Premium

Half-life

30-50 hours

Protein Binding

93%

Metabolized By

CYP3A4, CYP3A5

External

Drugs.com

Mechanism of action

Blocks L-type calcium channels in vascular smooth muscle, causing vasodilation

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·HER2-negative Breast Cancer
·Metastatic Breast Cancer
·Metaplastic Breast Carcinoma
·TNBC - Triple-Negative Breast Cancer
·Hypertension

Interactions

No curated interaction pairs are recorded for Amlodipine. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Peripheral edema
Dizziness
Flushing
Headache

Food, alcohol & herbal

Food

Grapefruit juice may increase levels

Alcohol · moderate

Additive hypotension

Pharmacokinetics

Half-life: 30-50 hours
Protein binding: 93%
Metabolised by: CYP3A4

Pregnancy & lactation

Not recorded for Amlodipine. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement