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  3. /Allopurinol

Allopurinol

Zyloprim, Aloprim

Antigout • Xanthine oxidase inhibitor

Premium
Nephrotoxic

Half-life

1-2 hours (active metabolite 18-30 hours)

Protein Binding

Metabolized By

N/A

External

Drugs.com

Mechanism of Action

Inhibits xanthine oxidase, reducing uric acid production

Indications(5)

Salt; ExcessBlood Pressure DisordersGoutTophaceous GoutAdenylosuccinate Lyase Deficiency

Classification

Drug Class

Antigout

Subclass

Xanthine oxidase inhibitor

Brand Names

ZyloprimAloprim

Key Properties

Half-life

1-2 hours (active metabolite 18-30 hours)

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Allopurinol Drug Profile | PharmaGraphX