Alendronate

Fosamax, Binosto

Bisphosphonate • Nitrogen-containing bisphosphonate

Nephrotoxic

Half-life

>10 years (in bone)

Protein Binding

78%

Metabolized By

N/A

External

Inhibits osteoclast-mediated bone resorption by binding to hydroxyapatite

Drug Class

Bisphosphonate

Subclass

Nitrogen-containing bisphosphonate

FosamaxBinosto

Half-life

>10 years (in bone)

Time for plasma concentration to decrease by 50%

Protein Binding

78%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses